Multi Channel BIABOOSTER
Innovative High sensitivity systems that integrate BIABooster technology.
Multi Channel CE
Capillary Electrophoresis system enabling parallel processing of 4 samples simultaneously.
BIABOOSTER CE pack
Plugin for capillary electrophoresis commercial systems.
ZETALIF Detectors
High sensitivity Lasers & LED induced fluorescence detectors for Capillary Electrophoresis, HPLC systems.
Application Kits
cfDNA, DNA, RNA, HMW DNA.
DNA analysis services
Custom methods development.
Our capillary electrophoresis BIABooster systems and fluorescence detectors are designed for high sensitivity, reproducibility and efficient analysis of a wide range of biomolecules.
The Multi Channel BIABooster platform is a four-channel Capillary Electrophoresis Instrument designed for DNA and RNA analysis, especially using BIABooster technology.
The platform includes several innovative features to offer altogether a great sensitivity in DNA size and concentration measurements, even for unpurified samples, and a very large size range from 0.1 to more than 100 kbp.
BIABooster devices are pre-assembled in ready-to-use cassettes. Installation of the cassettes within the instrument is straightforward, with a self-alignment of the capillary in front of the detection head. You don’t need any special tool or alignment procedure!
Samples are loaded in a 96-well microplate, with a minimum of 10 µl. The temperature of the microplate is regulated at dew point to avoid evaporation while waiting, keeping sample concentration untouched until analysis.
With the Multi Channel BIABooster, sample analysis is fully automated, from sample to results. The system converts raw data into meaningful results, proposing several ways of watching at the results. You can choose to look at the raw data, at sample concentration according to migration time, or at sample concentration according to DNA/RNA size. You also can determine sample concentration in any size window or compare several samples at once.
Several features are built-in within the instrument and its software to ascertain the quality of the results.
A QC report is available for all your runs.
BIABooster size-separation of DNA.
This unique feature enables to inject ~1µL in the capillary device, instead of a few nanoliters injected usually in a plain capillary (see “Discover our technology“).
The usual LOD for DNA fragments inside the size range of an DNA analysis kit is around 10 fg/µL (or 10 pg/mL). Using a multiple injection method, a further 10X increase in sensitivity can be achieved, reaching an LOD of 1 fg/µL (see “Applications Notes AN 2.009“)
During concentration, BIABooster technology can also purify DNA, washing away salts and other biochemical, since DNA, even fragmented, is a large molecule and highly charged (see “Discover our technology“).
So, you can determine the size profile of extracellular DNA from minute amount of plasma, without needing to extract it before.
This makes the Multi Channel BIABooster, the ideal tool to control the quality of a sample regarding circulating cell-free DNA (cfDNA), or even to investigate cfDNA size profile as a simple and powerful monitoring biomarker (see “Clinical studies“).
Separating large DNA is easy with the BIABooster technology.
Using the DNA 100K kit, you will visualise your genomic DNA as you never were able to see it!
Figure shows 3 different preparations of genomic DNA, producing obviously different fragment sizes. Choose the one adapted to your analytical workflow!
Voltage can be applied in one or the other polarity, from to 0 to 30000 V. Electric current is measured in each of the 4 capillaries.
So, standard electrophoresis of DNA or RNA is possible, with an effective length of 13 or 24 cm.
The internal high pressure enables a fast replacement of gel inside the capillaries. When necessary, stringent washes can also be applied with washing or conditioning solutions.
The figure shows the electrophoresis of an RNA ladder up to 10 kb (see “Kit RNA10K“) ; the ideal tool to check the quality of viral RNA constructed for vaccines or other therapeutics.
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