Analysis of circulating cell-free DNA
A powerful Quality Control of ccfDNA :
Quantify reliably DNA concentration;
Avoid sending to sequencing too degraded DNA
Detect high molecular weight DNA coming from leucocytes during pre-analytical steps;
A potential generic biomarker:
Very numerous studies show an increase of ccfDNA concentration related to pathology, in cancer, sepsis, inflammation, etc.
Numerous studies indicate that adding an integrity index to DNA concentration drastically increases the diagnostic/prognostic value of ccfDNA in cancer.
Potential to monitor therapeutic response, to monitor survivors during remission, …
Circulating Cell-free DNA (ccfDNA) is now recognized as a potential biomarker enabling personalized medicine for a wide range of pathologies.